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2004 Cancer Grant Recipients
Richard Bankert, VMD, Ph.D., SUNY Buffalo, professor, breast cancer research. Will develop a new method for producing cancer vaccine to eradicate tumors and prevent breast cancer recurrences.
Sharon Cantor, Ph.D., U. Mass Medical School, assistant professor, breast cancer research. Will investigate a protein, BACH1, that interacts with the breast cancer susceptibility gene, BRCA1. BACH1 is a helicase, unwinds DNA and may be important in DNA repair. The study will determine if this protein is altered in breast cancer.
Sudhansu Dey, Ph.D., Vanderbilt Medical Center, professor, ovarian cancer research. Will investigate the effects of a nonsteroidal, anti-inflammatory drug to determine (using an animal model) if it will decrease the risk of ovarian cancer.
Leif Ellisen, Ph.D., Massachusetts General, assistant professor, breast cancer research. Will use bioinformatics and gene expression profiling to identify genes regulated by p53 (a critical tumor suppressor that is altered in almost all cancers).
William Holloman, Ph.D., Weill Medical College of Cornell University, professor, breast cancer research. Will screen chemical compounds that repair DNA in the absences of a breast cancer susceptibility gene, BRCA2. This could identify new cancer prevention strategies.
Robert Jaffe, M.D., UCSF Comprehensive Cancer Center, professor, ovarian cancer research. Will test a novel cancer therapy involving combining compounds that prevent blood vascular formation around tumors with a mitosis inhibitor in an animal model of ovarian cancer.
Alessandra Santin, M.D., University of Arkansas Medical Sciences, assistant professor, ovarian cancer research. Will investigate a novel therapy for ovarian cancer based on the finding that ovarian cancer cells express cancer-specific epithelial cell surface receptors.
Richard Schlegel, M.D., Ph.D., Georgetown University Medical School, professor, cervical cancer research. Will investigate a Chinese herbal compound, artemisin, that may kill cervical cancer cells when applied topically.
Victoria Seewaldt, M.D., Duke University School of Medicine, associate professor, breast cancer research. Will investigate genes involved in vitamin A processing to determine if their loss is associated with increased risk for developing breast cancer.

Ann Thor, M.D., Oklahoma University Health Sciences, professor, breast cancer research. Will test if a synthetic thyroid hormone prescribed for patients actually promotes breast cancer growth by activation of the estrogen receptor.







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